5'-CMP (NIKKOL)

High-purity nucleotide.

It is a high-purity nucleotide obtained from yeast RNA through a selective enzymatic process developed by Yamasa Corporation. The active ingredient was developed based on the “Mini-RNA” concept, inspired by the biology of breast milk, where 5’-CMP is the most abundant nucleotide, acting to strengthen and regenerate the skin.

5’-CMP participates in the synthesis of phospholipids and ceramides, contributing to the strengthening and organization of the skin barrier. Its action stimulates the production of structural lipids essential for maintaining skin integrity, promoting greater cellular cohesion, skin resilience, and reduced water loss.

The active ingredient acts as a biological signal for the synthesis of phospholipids, sphingomyelins, and long-chain ceramides with a chain length greater than C22. These high-quality lipids help strengthen the skin barrier and promote immediate and long-lasting hydration—important characteristics for healthy, resilient skin with improved structural quality.

Helps strengthen the skin barrier.
It participates in the synthesis of phospholipids.
Stimulates the production of long-chain ceramides, greater than C22.
Promotes the production of sphingomyelins.
Contributes to immediate and long-lasting hydration.
Helps reduce water loss.
Stimulates the synthesis of type I collagen.
Helps protect against oxidative stress.
Reduces the formation of reactive oxygen species (ROS).
Modulates UVB-induced inflammatory mediators.
Promotes collagen maintenance.
Helps improve skin texture, radiance, and evenness.
Helps reduce fine lines associated with dryness.

Usual concentration

0.25% to 2.0%.

stability pH

pH 3.0 to 10.0

Stability temperature: 85°C for up to 4 hours.

5'-CMP (NIKKOL)

High-purity nucleotide.

Mini-RNA for Advanced Skin Resilience

Composition

0.25% to 2.0%.

pH 3.0 to 10.0

International Certificates

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