WHITONYL® (SILAB)

Whitonyl® has been studied to address hyperpigmentation on three fronts:

• Reduction of melanin production:
It decreases tyrosinase enzyme activity by up to 27%, limiting the early stages of melanogenesis.
It reduces overall melanin synthesis by up to 52% to 2%, outperforming kojic acid under equivalent conditions.

• Blocking pigment transport:
It reduces the expression of Rab27a—a protein involved in melanosome transport—by up to approximately 31%, limiting the pigment’s reach to the outermost layers of the skin.

• Control of photo-induced pigmentation (UVB):
In keratinocytes irradiated with UVB, it reduces the UV-induced increase in the stem cell factor (SCF)—an important mediator of sun-triggered pigmentation—by 81%.